Scripps Research Institute

Department Member, Cell Biology, Dorris Neuroscience Center

Research Associate

Dorris Neuroscience Center

Holly Cline

About

Research Interests
▪Of paramount importance in building a brain is controlling the number of cells that are generated. Retinal ganglion cells from the eye synapse onto neurons in the tectum and form the major information processing circuit of the visual system in non-mammalian vertebrates. Throughout the development of Xenopus laevis tadpoles, new neurons in the visual system are continuously generated and these cellular newcomers must integrate into the functional circuitry of an already visually-responsive and behaving animal. I am interested in how an animal’s experience works with cellular mechanisms to regulate cell proliferation in the developing brain.

▪Synaptic plasticity and morphological plasticity progress hand in hand: strong synapses stabilize the dendritic arbor, supporting further dendritic growth and fortifying some connections over others. Dendritic transport and translation of mRNA affords a unique degree of spatial and temporal control over protein levels in the cell. I am interested in how an animal’s experience impacts the dendritic transport and translation of mRNA and how these processes regulate neuronal development and plasticity.

Contact Information

Address:

Jennifer Bestman
10550 N. Torrey Pines Road
TSRI,  DNC 216
La Jolla, CA 92037

Telephone:

858 784 2219

 

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